Bayesian survival analysis in genetic association studies

Bayesian survival analysis in genetic association studies

MOTIVATION Large-scale genetic association studies are carried out with the hope of discovering single nucleotide polymorphisms involved in the etiology of complex diseases. There are several existing methods in the literature for performing this kind of analysis for case-control studies, but less work has been done for prospective cohort studies. We present a Bayesian method for linking marker...

Bayesian analysis of rare variants in genetic association studies.

Recent advances in next-generation sequencing technologies facilitate the detection of rare variants, making it possible to uncover the roles of rare variants in complex diseases. As any single rare variants contain little variation, association analysis of rare variants requires statistical methods that can effectively combine the information across variants and estimate their overall effect. ...

Simultaneous Bayesian analysis of contingency tables in genetic association studies.

Genetic association studies lead to simultaneous categorical data analysis. The sample for every genetic locus consists of a contingency table containing the numbers of observed genotype-phenotype combinations. Under case-control design, the row counts of every table are identical and fixed, while column counts are random. The aim of the statistical analysis is to test independence of the pheno...

Bayesian Modelling in Genetic Association Studies

Bayesian implementation of a genetic model-free approach to the meta-analysis of genetic association studies.

A genetic model-free method for the meta-analysis of genetic association studies is described that estimates the mode of inheritance from the data rather than assuming that it is known. For a bi-allelic polymorphism, with G as risk allele and g as wild-type, the genetic model depends on the ratio of the two log odds ratios, lambda = log OR(Gg)/log OR(GG), where OR(GG) compares GG with gg and OR...